In LGS, the epithelium on the villi of the small intestine becomes inflamed and irritated, which allows metabolic and microbial toxins of the small intestines to flood into the blood stream. This event compromises the liver, the lymphatic system, and the immune response, including the endocrine system. It is often the primary cause of the following:
Dr. Robynne Chutkan M.D.
Why The Microbiome Is The Future Of Medicine
Antibiotics have been the primary cause, but non-steroidal anti-inflammatory drugs (NSAIDs) are a major secondary cause. Antibiotics also damage the intestines by fostering the growth of Candida albicans and other pathogenic fungi and yeast. This overgrowth of yeast, more than any other factor, precipitates leaky gut syndrome. In a healthy situation, the small intestine epithelium maintains tight cell junctions, which contributes to the physical barrier involved in intestinal absorption. In addition to the physical barrier, there is an important chemical barrier within the mucus that contains immune agents which neutralize any toxins that come in contact with the intestinal lining.
Candida exudes an aldehyde secretion that causes small intestine epithelial cells to shrink. This allows intestinal toxins to infiltrate through the epithelium and into the blood. The secondary barrier-immune agents in the epithelial mucus-remain the sole agent for neutralization. Eventually, the immune system becomes exhausted by this continual challenge.
Leaky Gut Syndrome
Many people have an erroneous belief that the candida itself enters the blood stream, allowing it to be deposited elsewhere, such as the brain. Unless the immune response is completely depleted, as in AIDS, candida is quickly destroyed in the blood. The real damage done by candida is to the intestinal epithelial barrier, allowing the absorption of serious toxic agents and chemicals, which then enter the bloodstream and affect numerous organs, including the brain.
When the integrity of the intestinal barrier has been compromised, intestinal toxins are not the only pathogens to be absorbed. The barrier, in a healthy state, selectively allows digested nutrients to enter the small intestine when all is ready.
In the healing of the intestinal lining, exposure to a significant allergen can sabotage the treatment. For example, one may be very good at restricting wheat, dairy and eggs, but then compromises the treatment by eating peanut butter.
From here the lymphatic system will attempt to collect and neutralize the toxins, but, unable to send the toxins to the liver, the whole body starts to become toxic. In this environment, microbes flourish, which can cause chronic lymphatic swelling, especially in children. Over a period of time, toxins will be forced into distal connective tissue around muscles and joints, causing fibromyalgia, or into the cells, which can precipitate genetic mutation and ultimately cancer.
The immune system is stressed by leaky gut in three major ways.
The second stressor occurs in the liver and lymphatic system, which are also overwhelmed. This weakens the immune response.
The most important organ in the production of immune agents seems to be the adrenal gland, and leaky gut syndrome slowly diminishes adrenal function. In the early and middle stages, there is actually an adrenal excess, as measured by excess cortisol output. Eventually, cortisol levels drop, and one now experiences adrenal exhaustion.
Candida flourishes when the terrain in the intestines favors it. Just killing candida is usually not successful, because the chemistry and vitality of the terrain has not been normalized, and candida returns. The terrain of the small intestine requires proper PH and electromagnetic resonance.
Leaky gut syndrome has various components, all of which must be evaluated and addressed.
First, ongoing irritants to the small intestine mucosal lining (fungus, food allergens, and NSAIDs) need to be identified and neutralized.
Second, nutrients and herbs are required to promote healing of the epithelial lining.
Third, and perhaps the key link, the liver needs to be supported.
Fourth, the lymphatic and interstitial fluids need to be detoxified.
Fifth, the immune and endocrine systems need to be balanced and supported.
And sixth, the stomach and pancreas needs to be supported, if necessary.
The therapy for healing leaky gut syndrome takes between four and eight months. Here are some of the products that may be helpful. Each case requires careful evaluation, selecting remedies appropriate to the individual's specific needs.
I have found the following products very effective for leaky gut.
Kimberly D. Balas has an N.D. from Clayton College and a Ph. D. in Bioelectrical Engineering. She is a professional iridologist with the International Iridology Practitioners Association and an instructor in NSP's NHC program.
INTERVIEW WITH DR. PERLMUTTER M.D.
The link between the gut and the brain
Given that the microbiome composition and diversity change over time, it is tempting to speculate that the blood-brain barrier integrity also may fluctuate depending on the microbiome. This knowledge may be used to develop new ways for opening the blood-brain-barrier to increase the efficacy of the brain cancer drugs and for the design of treatment regimes that strengthens the integrity of the blood-brain barrier. - See more here
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